Genetic causes of spermatogenic failure.

I-34: NRY Haplotype Analysis: towards A Better Understanding of The Genetic Basis of Spermatogenic Failure

It has been established that the Y chromosome carries genes required for spermatogenesis and male fertility. For many decades worldwide screening for gene identification has been conducted in research laboratories. However, it has been a difficult process in identifying such genes (i.e. causative mutations) which could explain the phenotypic variation and could be potentially used as markers fo...

Premature Ovarian Failure: A Critical Condition in The Reproductive Potential with Various Genetic Causes

Copy number variations in spermatogenic failure patients with chromosomal abnormalities and unexplained azoospermia.

Male infertility is mostly caused by spermatogenic failure. Currently, routine genetic analyses of unexplained azoospermia or oligozoospermia are limited to the investigation of Y chromosomal microdeletions and chromosome karyotype analyses. The aim of this study was to find spermatogenic failure genes in patients with chromosomal abnormalities and unexplained azoospermia caused by copy number ...

Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene DMRT1

Gonadal failure, along with early pregnancy loss and perinatal death, may be an important filter that limits the propagation of harmful mutations in the human population. We hypothesized that men with spermatogenic impairment, a disease with unknown genetic architecture and a common cause of male infertility, are enriched for rare deleterious mutations compared to men with normal spermatogenesi...

P-53: Chronic Viral Infections and Infertility in Male

Background: The most common sexually transmitted diseases and the economic and social health problem throughout the world. However, vaccine coverage and antibiotic therapy and the development of programs to prevent and control major causes of acute and chronic diseases, pregnancy complications and infertility remains. Acute and chronic systemic viral infections can lead to infertility and perma...

Male infertility due to spermatogenic failure: current management and future perspectives

Spermatogenic failure has been recognized as the most severe presentation of male infertility in humans. Although it usually results in azoospermia. Approximately 30 to 60% of such men have sparse foci of sperm production within their dysfunctional testes, which can be extracted and used for in vitro fertilization techniques to produce a viable offspring. The scope of spermatogenic failure-rela...